Preprints and submitted manuscripts:
Electrochemical DABCOylation for challenging C–H amination reactions
Griffin Stewart, Eva Alvarez, Chris Rapala, Jonathan Sklar, Julia A. Kalow, and Christian A. Malapit
Patents:
Alvarez, E. M.; Bai, Z.; Ritter, T. A Bicyclopentyl Thianthrenium Compound, Process for Preparing the Same and the Use Thereof, Patent number EP22181685.3, Germany, (2024).
A General Hydrotrifluoromethylation of Unactivated Olefins Enabled by Voltage-Gated Electrosynthesis.
*Alvarez, E. M.; Li, J.; *Malapit, C. A.
Angew. Chem. Int. Ed. 2025, 64, e202415218. Link
Site-Selective Electrochemical Arene C–H Amination.
Alvarez, E. M.; Stewart, G.; Ullah, M.; Lalisse, R.; Gutierrez O.; Malapit, C. A.
J. Am. Chem. Soc. 2024, 146, 3591-3597. Link, Supporting information
Most read paper in JACS for the months of February and March.
Highlighted in Synfacts; Trauner, D., Etling, C. Synfacts 2024, 20, 0422.
Featured in Items of Interest to Process R&D Chemists
Org. Process Res. Dev. 2024, 28, 805 Link
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Invited for Organic Synthesis method article
Invited for Conceptual Review in ChemCatChem Concept
Bicyclopentylation for O-, N-, and C- Functionalization with a Storable Thianthrenium-based Reagent.
Alvarez, E. M.; Bai, Z.; Pandit, S.; Frank, N.; Torkowski, L.; Ritter, T.
Nat. Synth. 2023, 2, 548–556. Link
Highlighted in Aïssa, C. Storage without strain. Nat. Synth. 2023, 2, 478–480.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2023, 27, 993-1002.
Late-Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α-Amino Alkyl Radicals.
Alvarez, E. M.; Karl, T.; Berger, F.; Torkowski, L.; Ritter, T.
Angew. Chem. Int. Ed. 2024, 60, 13609-13613. Link
Selected as Hot Paper.
Among the top 10% most downloaded papers.
Cine-Substitutions at Five-Membered Hetarenes Enabled by Sulfonium Salts.
Berger F.; Alvarez, E. M.; Frank, N.; Bohdan, K.; Kondratiuk, M.; Torkowski, L.; Engl, P. S.; Barletta, J.; Ritter, T.
Org. Lett. 2020, 22, 5671-5674. Link
Site-Selective C–H Functionalization–Sulfination Sequence to Access Aryl Sulfonamides.
Alvarez, E. M.; Plutschack, M. B.; Berger, F.; Ritter, T.
Org. Lett. 2020, 22, 4593-4596. Link
Selected as Hot Paper.
Selected as Front Cover by the Editor.
Among the top 10% most downloaded papers.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2020, 24, 885−896.
Radical Carbofluorination of Alkenes with Arylhydrazines and Selectfluor: Additives, Mechanistic Pathways, and Polar Effects.
Pirzer, A. S.; Alvarez, E. M.; Friedrich, H.; Heinrich, M. R.
Chem. Eur. J. 2019, 25, 2786-2792. Link
Publications
Preprints and Submitted
Manuscripts
Electrochemical DABCOylation for challenging C–H amination reactions
Griffin Stewart, Eva Alvarez, Chris Rapala, Jonathan Sklar, Julia A. Kalow, and Christian A. Malapit.
Patents
Alvarez, E. M.; Bai, Z.; Ritter, T. A Bicyclopentyl Thianthrenium Compound, Process for Preparing the Same and the Use Thereof, Patent number EP22181685.3, Germany, (2024).
A General Hydrotrifluoromethylation
of Unactivated Olefins Enabled by
Voltage-Gated Electrosynthesis
*Alvarez, E. M.; Li, J.; *Malapit, C. A.
Angew. Chem. Int. Ed. 2025, 64, e202415218 Link
Site-Selective Electrochemical Arene
C–H Amination
Alvarez, E. M.; Stewart, G.; Ullah, M.; Lalisse, R.; Gutierrez O.; Malapit, C. A.
J. Am. Chem. Soc. 2024, 146, 3591-3597. Link , Supporting information
Bicyclopentylation for O-, N-, and
C- Functionalization with a Storable
Thianthrenium-based Reagent.
Alvarez, E. M.; Bai, Z.; Pandit, S.; Frank, N.; Torkowski, L.; Ritter, T.
Nat. Synth. 2023, 2, 548–556. Link
Highlighted in Aïssa, C. Storage without strain. Nat. Synth. 2023, 2, 478–480.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2023, 27, 993-1002.
Late-Stage Heteroarylation of
Hetero(aryl) sulfonium Salts
Activated by α-Amino Alkyl Radicals
Alvarez, E. M.; Karl,T.; Berger, F.; Torkowski, L.; Ritter, T.
Angew. Chem. Int. Ed. 2024, 60, 13609-13613. Link
Selected as Hot Paper.
Among the top 10% most downloaded papers.
Cine-Substitutions at Five-Membered
Hetarenes Enabled by Sulfonium Salts
Berger F.; Alvarez, E. M.; Frank, N.; Bohdan, K.; Kondratiuk, M.; Torkowski, L.; Engl, P. S.; Barletta, J.; Ritter, T.
Org. Lett. 2020, 22, 5671-5674. Link
Site-Selective C–H Functionalization
–Sulfination Sequence to Access Aryl
Sulfonamides
Alvarez, E. M.; Plutschack, M. B.; Berger, F.; Ritter, T.
Org. Lett. 2020, 22, 4593-4596. Link
Selected as Hot Paper.
Selected as Front Cover by the Editor.
Among the top 10% most downloaded papers.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2020, 24, 885−896.
Radical Carbofluorination of Alkenes
with Arylhydrazines and Selectfluor:
Additives, Mechanistic Pathways,
and Polar Effects
Pirzer, A. S.; Alvarez, E. M.; Friedrich, H.; Heinrich, M. R.
Chem. Eur. J. 2019, 25, 2786-2792. Link