Preprints and submitted manuscripts:
————————————————
Patents:
Alvarez, E. M.; Bai, Z.; Ritter, T. A Bicyclopentyl Thianthrenium Compound, Process for Preparing the Same and the Use Thereof, Patent number EP22181685.3, Germany, (2024).
Cooperative Boron-Copper Catalysis unlocks Alkyl Radicals from Amines
Trends in Chemistry. 2026, xx, xxx-xxx.
Alvarez, E. M.*
Electrochemical Oxidation enables Aromatic C–H Amination with Dual Mechanisms
Stewart G.; Alvarez, E. M.; Rapala, C.; Sklar, J. H.; Kalow, J. A.; Malapit, C. A.*
Nat. Synth. 2025, Accepted article, in press.
A General Hydrotrifluoromethylation of Unactivated Olefins Enabled by Voltage-Gated Electrosynthesis
Alvarez, E. M.*; Li, J.; Malapit, C. A.*
Angew. Chem. Int. Ed. 2025, 64, e202415218. Link
Site-Selective Electrochemical Arene C–H Amination
Alvarez, E. M.; Stewart, G.; Ullah, M.; Lalisse, R.; Gutierrez, O.; Malapit, C. A.*
J. Am. Chem. Soc. 2024, 146, 3591-3597. Link, Supporting information
Most read paper in JACS for the months of February and March.
Highlighted in Synfacts; Trauner, D., Etling, C. Synfacts 2024, 20, 0422.
Featured in Items of Interest to Process R&D Chemists
Org. Process Res. Dev. 2024, 28, 805 Link
Highlighted in ChemistryViews Link
Highlighted in ChemistryViews Link
Highlighted in Synthesis Workshop Youtube lecture. Video , Español
Invited for Organic Synthesis method article
Invited for Conceptual Review in ChemCatChem Concept
Bicyclopentylation for O-, N-, and C- Functionalization with a Storable Thianthrenium-based Reagent
Alvarez, E. M.; Bai, Z.; Pandit, S.; Frank, N.; Torkowski, L.; Ritter, T.*
Nat. Synth. 2023, 2, 548–556. Link
Highlighted in Aïssa, C. Storage without strain. Nat. Synth. 2023, 2, 478–480.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2023, 27, 993-1002.
Late-Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α-Amino Alkyl Radicals
Alvarez, E. M.; Karl, T.; Berger, F.; Torkowski, L.; Ritter, T.*
Angew. Chem. Int. Ed. 2024, 60, 13609-13613. Link
Selected as Hot Paper.
Among the top 10% most downloaded papers.
Cine-Substitutions at Five-Membered Hetarenes Enabled by Sulfonium Salts
Berger F.; Alvarez, E. M.; Frank, N.; Bohdan, K.; Kondratiuk, M.; Torkowski, L.; Engl, P. S.; Barletta, J.; Ritter, T.*
Org. Lett. 2020, 22, 5671-5674. Link
Site-Selective C–H Functionalization–Sulfination Sequence to Access Aryl Sulfonamides
Alvarez, E. M.; Plutschack, M. B.; Berger, F.; Ritter, T.*
Org. Lett. 2020, 22, 4593-4596. Link
Selected as Hot Paper.
Selected as Front Cover by the Editor.
Among the top 10% most downloaded papers.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2020, 24, 885−896.
Radical Carbofluorination of Alkenes with Arylhydrazines and Selectfluor: Additives, Mechanistic Pathways, and Polar Effects
Pirzer, A. S.; Alvarez, E. M.; Friedrich, H.; Heinrich, M. R.*
Chem. Eur. J. 2019, 25, 2786-2792. Link
Publications
Preprints and Submitted
Manuscripts
Patents
Alvarez, E. M.; Bai, Z.; Ritter, T. A Bicyclopentyl Thianthrenium Compound, Process for Preparing the Same and the Use Thereof, Patent number EP22181685.3, Germany, (2024).
Cooperative Boron-Copper
Catalysis unlocks Alkyl Radicals
from Amines
Trends in Chemistry. 2026, xx, xxx-xxx.
Alvarez, E. M.*
Electrochemical oxidation enables
aromatic C–H amination with
dual mechanisms.
Stewart G., Alvarez E. M., Rapala C., Sklar J. H., Kalow J. A., Malapit C. A.*
Nature Synthesis. 2025, Accepted article, in press.
A General Hydrotrifluoromethylation
of Unactivated Olefins Enabled by
Voltage-Gated Electrosynthesis
*Alvarez, E. M.; Li, J.; *Malapit, C. A.
Angew. Chem. Int. Ed. 2025, 64, e202415218 Link
Site-Selective Electrochemical Arene
C–H Amination
Alvarez, E. M.; Stewart, G.; Ullah, M.; Lalisse, R.; Gutierrez O.; Malapit, C. A.
J. Am. Chem. Soc. 2024, 146, 3591-3597. Link , Supporting information
Bicyclopentylation for O-, N-, and
C- Functionalization with a Storable
Thianthrenium-based Reagent.
Alvarez, E. M.; Bai, Z.; Pandit, S.; Frank, N.; Torkowski, L.; Ritter, T.
Nat. Synth. 2023, 2, 548–556. Link
Highlighted in Aïssa, C. Storage without strain. Nat. Synth. 2023, 2, 478–480.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2023, 27, 993-1002.
Late-Stage Heteroarylation of
Hetero(aryl) sulfonium Salts
Activated by α-Amino Alkyl Radicals
Alvarez, E. M.; Karl,T.; Berger, F.; Torkowski, L.; Ritter, T.
Angew. Chem. Int. Ed. 2024, 60, 13609-13613. Link
Selected as Hot Paper.
Among the top 10% most downloaded papers.
Cine-Substitutions at Five-Membered
Hetarenes Enabled by Sulfonium Salts
Berger F.; Alvarez, E. M.; Frank, N.; Bohdan, K.; Kondratiuk, M.; Torkowski, L.; Engl, P. S.; Barletta, J.; Ritter, T.
Org. Lett. 2020, 22, 5671-5674. Link
Site-Selective C–H Functionalization
–Sulfination Sequence to Access Aryl
Sulfonamides
Alvarez, E. M.; Plutschack, M. B.; Berger, F.; Ritter, T.
Org. Lett. 2020, 22, 4593-4596. Link
Selected as Hot Paper.
Selected as Front Cover by the Editor.
Among the top 10% most downloaded papers.
Selected as OPR&D Highlights: Org. Process Res. Dev. 2020, 24, 885−896.
Radical Carbofluorination of Alkenes
with Arylhydrazines and Selectfluor:
Additives, Mechanistic Pathways,
and Polar Effects
Pirzer, A. S.; Alvarez, E. M.; Friedrich, H.; Heinrich, M. R.
Chem. Eur. J. 2019, 25, 2786-2792. Link